LymphedemaV1, Main, Exploration, bibRecord, 007E73

Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

Identifieur interne : 007E73 ( Main/Exploration ); précédent : 007E72; suivant : 007E74

Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

Auteurs : Claus Cursiefen ; Sakae Ikeda ; Patsy M. Nishina ; Richard S. Smith ; Akihiro Ikeda ; David Jackson ; Jun-Song Mo ; Lu Chen ; M. Reza Dana ; Bronislaw Pytowski ; Friedrich E. Kruse ; J. Wayne Streilein

Source :

The American Journal of Pathology [ 0002-9440 ] ; 2005.

RBID : PMC:1606392

Abstract

Lymphangiogenesis, the formation of new lymphatic vessels, is important for tumor metastasis and induction of immunity to peripheral antigens including organ transplants. We herein describe a novel mouse model of spontaneous, secondary lymphangiogenesis in the normally avascular cornea. corn1 mice, which suffer from a deletion in the gene encoding the cytoskeletal protein destrin, develop hemangiogenesis as well as spontaneous outgrowth of LYVE-1⁺⁺⁺/CD31⁺ lymphatic vessels into the cornea starting at age 4 weeks. Corneal lymphangiogenesis is delayed in onset, is less intense, and regresses earlier compared with hemangiogenesis. Moreover, the lymphangiogenesis is preceded only by a mild recruitment of CD45⁺ inflammatory cells into the cornea. In contrast to mice with inflammation-induced hem- and lymphangiogenesis, corn1 mice do not develop breakdown of the blood-aqueous barrier. Finally, in this novel mouse model, a blocking anti-VEGFR3 antibody significantly inhibited not only lymph- but also hemangiogenesis. In summary, destrin deletion has differential effects on spontaneous hem- and lymphangiogenesis in the normally avascular cornea and represents a novel mouse model to study the mechanisms of lymphangiogenesis and to test the antihem- and antilymphangiogenic properties of known or new antiangiogenic agents.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1606392

PubMed: 15855638
PubMed Central: 1606392

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Lymphangiogenesis, the formation of new lymphatic vessels, is important for tumor metastasis and induction of immunity to peripheral antigens including organ transplants. We herein describe a novel mouse model of spontaneous, secondary lymphangiogenesis in the normally avascular cornea. <bold><italic>corn1</italic>
</bold>
 mice, which suffer from a deletion in the gene encoding the cytoskeletal protein destrin, develop hemangiogenesis as well as spontaneous outgrowth of LYVE-1<sup>+++</sup>
/CD31<sup>+</sup>
 lymphatic vessels into the cornea starting at age 4 weeks. Corneal lymphangiogenesis is delayed in onset, is less intense, and regresses earlier compared with hemangiogenesis. Moreover, the lymphangiogenesis is preceded only by a mild recruitment of CD45<sup>+</sup>
 inflammatory cells into the cornea. In contrast to mice with inflammation-induced hem- and lymphangiogenesis, <bold><italic>corn1</italic>
</bold>
 mice do not develop breakdown of the blood-aqueous barrier. Finally, in this novel mouse model, a blocking anti-VEGFR3 antibody significantly inhibited not only lymph- but also hemangiogenesis. In summary, destrin deletion has differential effects on spontaneous hem- and lymphangiogenesis in the normally avascular cornea and represents a novel mouse model to study the mechanisms of lymphangiogenesis and to test the antihem- and antilymphangiogenic properties of known or new antiangiogenic agents.</p>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name>
<name sortKey="Cursiefen, Claus" sort="Cursiefen, Claus" uniqKey="Cursiefen C" first="Claus" last="Cursiefen">Claus Cursiefen</name>
<name sortKey="Dana, M Reza" sort="Dana, M Reza" uniqKey="Dana M" first="M. Reza" last="Dana">M. Reza Dana</name>
<name sortKey="Ikeda, Akihiro" sort="Ikeda, Akihiro" uniqKey="Ikeda A" first="Akihiro" last="Ikeda">Akihiro Ikeda</name>
<name sortKey="Ikeda, Sakae" sort="Ikeda, Sakae" uniqKey="Ikeda S" first="Sakae" last="Ikeda">Sakae Ikeda</name>
<name sortKey="Jackson, David" sort="Jackson, David" uniqKey="Jackson D" first="David" last="Jackson">David Jackson</name>
<name sortKey="Kruse, Friedrich E" sort="Kruse, Friedrich E" uniqKey="Kruse F" first="Friedrich E." last="Kruse">Friedrich E. Kruse</name>
<name sortKey="Mo, Jun Song" sort="Mo, Jun Song" uniqKey="Mo J" first="Jun-Song" last="Mo">Jun-Song Mo</name>
<name sortKey="Nishina, Patsy M" sort="Nishina, Patsy M" uniqKey="Nishina P" first="Patsy M." last="Nishina">Patsy M. Nishina</name>
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Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

Spontaneous Corneal Hem- and Lymphangiogenesis in Mice with Destrin-Mutation Depend on VEGFR3 Signaling

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Abstract

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